Description
Product name CAS:224638-84-0:Albiglutide fragment
Albiglutide fragment is the core active peptide segment of albiglutide, composed of two tandem GLP-1 analog sequences. It highly specifically activates GLP-1 receptors, promotes insulin secretion in a glucose-dependent manner, inhibits glucagon, and delays gastric emptying. Applied in mechanism research of type 2 diabetes, obesity and GLP-1 peptide drug development.
Peptide purity (HPLC, %) 95%/98%/99%
Theoretical molecular weight: ~7.0 kDa (dimer peptide)
Modification type: Tandem repeat sequence, C-terminal amidation
| 1: Product Basic Information Table | ||||||||
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Full Amino Acid Sequence | Molecular Formula | Exact Mass (Da) | Average MW (Da) | Terminal Modification | Sequence Length (aa) |
| Albiglutide fragment | Albiglutide fragment; GLP-1 dimer peptide; CAS 224638-84-0 | GLP-1 receptor agonism,Glucose lowering & weight loss,Long-acting action,Type 2 diabetes study,Tandem dimer,Metabolic drug development | Two tandem GLP-1 analog sequences with C-terminal amidation | Large polypeptide, no precise small-molecule formula; subject to actual batch MS | - | ~7000 (theoretical) | N-terminal free amine, C-terminal amidation | ~62 (dimer) |
| 2: Physicochemical Solubility & Storage Parameters | ||||||||
| Product Code | Appearance | Long-term Storage Conditions | Short-term Storage Conditions | Liquid Stability | Solid Powder Stability | |||
| PEP-ALB001 | white powder | Store at -20℃, sealed, dry & protected from light, aliquoted; avoid repeated freeze-thaw and vigorous shaking | Solid powder stable for 1 year at 2-8℃ sealed and dry; reconstituted solution can be stored short-term at 2-8℃ | Stable for 7 days at 4℃ under sterile conditions; stable for 2 months at -20℃ in aliquots. **Good water solubility, freely soluble in water and physiological buffer**. Repeated freeze-thaw causes peptide aggregation and activity reduction; prone to self-aggregation at high concentration | Stable for over 2 years at -20℃ under dry & dark conditions | |||
| 3: Functional Description | ||||||||
| Product Code | Frontend Short Summary (for search list display) | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Targets / Pathways | ||||
| PEP-ALB001 | Tandem dimer GLP-1 receptor agonist peptide with long-acting glucose lowering and weight loss, improving glucolipid metabolic disorders | Albiglutide fragment binds to two GLP-1 receptor extracellular domains simultaneously via tandem repeated GLP-1 active sequences, enhancing receptor dimerization efficiency and downstream signal intensity. It exerts multiple metabolic regulatory effects: glucose-dependent insulin secretion promotion, glucagon inhibition, delayed gastric emptying, and reduced food intake. The tandem structure improves enzymatic resistance and receptor affinity, with longer in vivo action time than monomer GLP-1 analogs. This peptide serves as a core tool molecule for GLP-1 long-acting drug SAR research, type 2 diabetes and obesity mechanism analysis, and dual receptor binding mode verification. | Type 2 diabetes study,Obesity mechanism study,GLP-1 pathway study,Long-acting peptide development,Glucolipid metabolism research,Islet function study | Glucagon-Like Peptide-1 Receptor (GLP-1R); cAMP/PKA signaling pathway; Glucolipid metabolism and energy intake regulatory pathway |
热门标签: Albiglutide FragmentCAS:224638-84-0,治疗和药物肽